1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one

Base Information

• Chemical Name: 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one
• CAS No.: 1057215-52-7
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395

Synonyms:1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one

Chemical Property of 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one

There total 2 articles about 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-(2R,3R)-oxiran-2-ylmethanol (98819-68-2) + 1-propyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (77557-01-8) → 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one (1057215-52-7)

Guidance literature:

1-propyl-1,3-dihydro-2H-benzo[d]imidazol-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

3-phenyl-(2R,3R)-oxiran-2-ylmethanol; With titanium(IV) isopropylate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm900888c

Reference yield:

→ 1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one (1057215-52-7)

Guidance literature:

Reference yield:

1-propyl-3-[(1S,2S)-2,3-dihydroxy-1-phenyl-propyl]-1,3-dihydro-2H-benzimidazol-2-one (1057215-52-7) + p-toluenesulfonyl chloride (98-59-9) → C26H28N2O5S

Guidance literature:

In pyridine; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm900888c

upstream raw materials:

3-phenyl-(2R,3R)-oxiran-2-ylmethanol

1-propyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

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