1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

Base Information

Chemical Name:1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine
CAS No.:496788-68-2
Molecular Formula:C₃₁H₂₆Cl₃NO₅
Molecular Weight:598.91
Hs Code.:

Synonyms:1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

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Chemical Property of 1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

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Technology Process of 1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

There total 3 articles about 1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₉H₉BrMgO₂

: 1-benzhydryl-3-(methoxycarbonyl)pyridinium bromide

: 4124-31-6
trichloroacetic acid anhydride

: 496788-68-2
1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

Guidance literature:: C₉H₉BrMgO₂; With copper(l) iodide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

1-benzhydryl-3-(methoxycarbonyl)pyridinium bromide; In tetrahydrofuran; at -40 - 20 ℃; for 3h;

trichloroacetic acid anhydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4020(02)00941-9

Reference yield:

: 93-60-7
methyl 3-pyridinecarboxylate

: 496788-68-2
1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / acetone / 264 h / 20 °C

2.1: CuI / tetrahydrofuran / 1 h / -78 - 20 °C

2.2: tetrahydrofuran / 3 h / -40 - 20 °C

2.3: 55 percent / tetrahydrofuran / 20 °C

With copper(l) iodide; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4020(02)00941-9

Reference yield:

: 776-74-9
Bromodiphenylmethane

: 496788-68-2
1-benzhydryl-4-[2-(ethoxycarbonyl)phenyl]-3-(methoxycarbonyl)-5-(trichloroacetyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / acetone / 264 h / 20 °C

2.1: CuI / tetrahydrofuran / 1 h / -78 - 20 °C

2.2: tetrahydrofuran / 3 h / -40 - 20 °C

2.3: 55 percent / tetrahydrofuran / 20 °C

With copper(l) iodide; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4020(02)00941-9