7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Base Information

Chemical Name:7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester
CAS No.:261772-69-4
Molecular Formula:C₃₇H₆₆O₆Si₂
Molecular Weight:663.098
Hs Code.:

7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Synonyms:7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

There total 13 articles about 7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 261772-00-3
7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-heptanoic acid methyl ester

: 261772-69-4
7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -70 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 261772-69-4
7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / imidazole / dimethylformamide / 20 °C

2.1: Cp₂ZrClH / tetrahydrofuran / 0.75 h / 20 °C

2.2: 80 percent / I₂ / tetrahydrofuran / 0.25 h / 0 °C

3.1: t-BuLi / diethyl ether; pentane / 1 h / -70 °C

3.2: 70 percent / lithium 2-thienylcyanocuprate / diethyl ether; pentane; tetrahydrofuran / -70 - -20 °C

4.1: 62 percent / L-selectride / tetrahydrofuran / 1 h / -70 °C

With 1H-imidazole; Schwartz's reagent; tert.-butyl lithium; L-Selectride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 253350-38-8
(3S)-4-(3-methoxymethylphenyl)-1-butyn-3-ol

: 261772-69-4
7-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-hydroxy-cyclopentyl}-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / imidazole / dimethylformamide / 20 °C

2.1: Cp₂ZrClH / tetrahydrofuran / 0.75 h / 20 °C

2.2: 80 percent / I₂ / tetrahydrofuran / 0.25 h / 0 °C

3.1: t-BuLi / diethyl ether; pentane / 1 h / -70 °C

3.2: 70 percent / lithium 2-thienylcyanocuprate / diethyl ether; pentane; tetrahydrofuran / -70 - -20 °C

4.1: 62 percent / L-selectride / tetrahydrofuran / 1 h / -70 °C

With 1H-imidazole; Schwartz's reagent; tert.-butyl lithium; L-Selectride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0968-0896(02)00031-7