1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester
• CAS No.: 98996-29-3
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Hs Code.: 2933399090
• Mol file: 98996-29-3.mol

Synonyms:Isonicotinicacid, 1,2-dihydro-1-methyl-2-oxo-, ethyl ester (6CI);NSC 21089;

Chemical Property of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 319.2 °C at 760 mmHg
• Flash Point: 146.8 °C
• PSA: 48.30000
• Density: 1.186 g/cm³
• LogP: 0.56200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

ethyl1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

There total 7 articles about 1-Methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester (98996-29-3)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

3: K₃; aqueous alkaline solution

4: SOCl₂

With thionyl chloride; alkaline solution; potassium hexacyanoferrate(III);

DOI:10.1021/jo01084a011

Reference yield:

isopropyl pyridine-4-carboxylate (125294-42-0) → 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester (98996-29-3)

Guidance literature:

Multi-step reaction with 3 steps

2: K₃; aqueous alkaline solution

3: SOCl₂

With thionyl chloride; alkaline solution; potassium hexacyanoferrate(III);

DOI:10.1021/jo01084a011

Reference yield:

4-isopropyloxycarbonyl-1-methylpyridinium iodide (111961-69-4) → 1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid ethyl ester (98996-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₃; aqueous alkaline solution

2: SOCl₂

With thionyl chloride; alkaline solution; potassium hexacyanoferrate(III);

DOI:10.1021/jo01084a011

upstream raw materials:

1-methyl-2-oxo-1,2-dihydro-4-pyridinecarboxylic acid

ethanol

Trifluoro-methanesulfonate2-chloro-4-ethoxycarbonyl-1-methyl-pyridinium;

Trifluoro-methanesulfonate2-bromo-4-ethoxycarbonyl-1-methyl-pyridinium;

Downstream raw materials:

1-methyl-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid hydrazide