4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

Base Information

Chemical Name:4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide
CAS No.:1609243-01-7
Molecular Formula:C₂₂H₂₃N₅O₄S
Molecular Weight:453.522
Hs Code.:

Synonyms:4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

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Chemical Property of 4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

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Technology Process of 4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

There total 6 articles about 4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 16312-79-1
4-methylurazole

: 1609243-06-2
N-allyl-N-phenyl-(N'-benzyl-N'-(2-propynyl))sulfamide

: 1609243-01-7
4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

Guidance literature:: N-allyl-N-phenyl-(N'-benzyl-N'-(2-propynyl))sulfamide; With Grubbs catalyst first generation; In toluene; at 50 ℃; for 15h; Inert atmosphere;

4-methylurazole; In toluene; for 5h; diastereoselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2014.04.014

Reference yield:

: 1609243-03-9
N-allyl-N-phenyl-(N'-tert-butoxycarbonyl)sulfamide

: 1609243-01-7
4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere

4.1: Grubbs catalyst first generation / toluene / 15 h / 50 °C / Inert atmosphere

4.2: 5 h / Inert atmosphere; Reflux

With Grubbs catalyst first generation; 18-crown-6 ether; potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; 4.1: |Diels-Alder Cycloaddition / 4.2: |Diels-Alder Cycloaddition;
DOI:10.1016/j.tet.2014.04.014

Reference yield:

: 1609243-04-0
N-allyl-N-phenyl-(N'-tert-butoxycarbonyl-N'-(2-propynyl))sulfamide

: 1609243-01-7
4-benzyl-10-methyl-2-phenyl-4,5,10,12a-tetrahydro-1H-[1,2,4]triazolo[10,20:1,2]pyridazino[3,4-d][1,2,7]thiadiazepine-9,11-dione 3,3-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere

3.1: Grubbs catalyst first generation / toluene / 15 h / 50 °C / Inert atmosphere

3.2: 5 h / Inert atmosphere; Reflux

With Grubbs catalyst first generation; 18-crown-6 ether; potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene; 3.1: |Diels-Alder Cycloaddition / 3.2: |Diels-Alder Cycloaddition;
DOI:10.1016/j.tet.2014.04.014