benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

Base Information

Chemical Name:benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate
CAS No.:160785-87-5
Molecular Formula:C₂₄H₂₃N₃O₆S
Molecular Weight:481.529
Hs Code.:

Synonyms:benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

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Chemical Property of benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

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Technology Process of benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

There total 3 articles about benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 624-83-9
methyl isocyanate

: 49599-37-3
diphenylmethyl 7-formamido-3-hydroxymethyl-Δ³-cephem-4-carboxylate

: 160785-87-5
benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 8h;
DOI:10.7164/antibiotics.47.1507

Reference yield:

: 27267-35-2
7-formylamino-3-acetoxymethyl-3-cephem-4-carboxylic acid

: 160785-87-5
benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOAc; phosphate buffer, wheat bran, 2.) 1M HCl / 1.) H₂O, 18 h, pH 6.5, 2.) CH₂Cl₂, H₂O, 20 deg C, 14 h, pH 2.8

2: 38 percent / Et₃N / tetrahydrofuran / 8 h / 50 °C

With hydrogenchloride; phosphate buffer; wheat bran; sodium acetate; triethylamine; In tetrahydrofuran;
DOI:10.7164/antibiotics.47.1507

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 160785-87-5
benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) acetic anhydride / 1.) 40 deg C, 30 min, 2.) r.t., 2 h

2: 1.) NaOAc; phosphate buffer, wheat bran, 2.) 1M HCl / 1.) H₂O, 18 h, pH 6.5, 2.) CH₂Cl₂, H₂O, 20 deg C, 14 h, pH 2.8

3: 38 percent / Et₃N / tetrahydrofuran / 8 h / 50 °C

With hydrogenchloride; phosphate buffer; wheat bran; sodium acetate; acetic anhydride; triethylamine; In tetrahydrofuran;
DOI:10.7164/antibiotics.47.1507