(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

Base Information

Chemical Name:(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol
CAS No.:1599531-68-6
Molecular Formula:C₂₇H₂₇ClF₃N₅O₃S
Molecular Weight:594.057
Hs Code.:

Synonyms:(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

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Chemical Property of (4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

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Technology Process of (4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

There total 9 articles about (4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₅ClF₃N₅O

: 124-63-0
methanesulfonyl chloride

: 1599531-68-6
(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

Guidance literature:: With triethylamine; In dichloromethane; for 0.416667h; Cooling with ice;

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1599531-68-6
(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 0.58 h / 20 °C / Cooling with ice

1.2: 2.53 h

2.1: toluene-4-sulfonic acid / toluene / 18 h / 125 °C / Dean-Stark

3.1: trichlorophosphate / acetonitrile / 1.08 h / 90 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

4.2: 0.5 h / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 18.33 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 0.42 h / Cooling with ice

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; toluene; acetonitrile; mineral oil;

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1599531-68-6
(4-chloro-2-ethyl-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-1,2,3-triazol-5-yl)(1-(methylsulfonyl)azetidin-3-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 0.58 h / 20 °C / Cooling with ice

1.2: 2.53 h

2.1: toluene-4-sulfonic acid / toluene / 18 h / 125 °C / Dean-Stark

3.1: trichlorophosphate / acetonitrile / 1.08 h / 90 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

4.2: 0.5 h / Cooling with ice

5.1: trifluoroacetic acid / dichloromethane / 18.33 h / 20 °C / Cooling with ice

6.1: triethylamine / dichloromethane / 0.42 h / Cooling with ice

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; toluene; acetonitrile; mineral oil;