2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester
• CAS No.: 168421-50-9
• Molecular Formula: C₁₅H₂₀O₈
• Molecular Weight: 328.319
• Mol file: 168421-50-9.mol

Synonyms:2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester

Chemical Property of 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester

There total 2 articles about 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

lithium dimethyl malonate (74826-01-0) + 2-Bromo-1,4-bis(methoxymethoxy)benzene (131136-47-5) → 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester (168421-50-9)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo951560x

Reference yield: 71.0%

2-Bromo-1,4-bis(methoxymethoxy)benzene (131136-47-5) + malonic acid dimethyl ester (108-59-8) → 2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester (168421-50-9)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield: 99.0%

2-Methoxycarbonylmethyl-3,6-bis-methoxymethoxy-benzoic acid methyl ester (168421-50-9) → 2-Carboxymethyl-3,6-bis-methoxymethoxy-benzoic acid (168421-51-0)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1021/ja960040w

upstream raw materials:

2-Bromo-1,4-bis(methoxymethoxy)benzene

malonic acid dimethyl ester

lithium dimethyl malonate

Downstream raw materials:

2-Carboxymethyl-3,6-bis-methoxymethoxy-benzoic acid