Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester
CAS No.:83866-36-8
Molecular Formula:C₃₅H₄₀ClN₁₀O₁₃P
Molecular Weight:875.189
Hs Code.:

Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Synonyms:Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

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Chemical Property of Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

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Technology Process of Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

There total 4 articles about Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 83866-32-4
C₅₆H₅₈ClN₁₀O₁₅P

: 83866-36-8
Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: In water; acetic acid; at 20 ℃; for 0.75h;

Reference yield:

: 68892-41-1
5'-dimethoxytriphenylmethyl-N²-isobutyryl-2'-deoxyguanosine

: 83866-36-8
Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2. 4-dimethylaminopyridine / 1. THF, 2 h; 2. THF, 20 h

2: 90 percent / H₂O; acetic acid / 0.75 h / 20 °C

With dmap; In water; acetic acid;

Reference yield:

: 80614-99-9
3'-O-formyl-N-isobutyryl-2'-deoxyguanosine

: 83866-36-8
Formic acid (2R,3S,5R)-2-{(2-chloro-phenoxy)-[(2R,3S,5R)-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxy]-phosphoryloxymethyl}-5-(6-hydroxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2. 4-dimethylaminopyridine / 1. THF, 2 h; 2. THF, 20 h

2: 90 percent / H₂O; acetic acid / 0.75 h / 20 °C

With dmap; In water; acetic acid;