Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

Base Information

• Chemical Name: Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)
• CAS No.: 1373945-10-8
• Molecular Formula: C₂₃H₃₃Cl₃FN₅O₄RuS₂
• Molecular Weight: 734.106
• Mol file: 1373945-10-8.mol

Synonyms:Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

Chemical Property of Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

There total 4 articles about Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

cis-[Ru(dmso)4Cl2] + C19H21ClFN5O2*BrH (1373944-10-5) → C23H33Cl3FN5O4RuS2 (1373945-10-8)

Guidance literature:

In ethanol; at 80 ℃; for 6h;

Reference yield: 55.0%

cis-RuCl2(dmso)4 + 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline (1360859-35-3) → RuIICl2(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline) (1373945-10-8)

Guidance literature:

In ethanol; at 111.84 ℃; for 6h;

DOI:10.1016/j.ejmech.2014.02.062

Reference yield:

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline (184475-71-6) → C23H33Cl3FN5O4RuS2 (1373945-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 87 °C

1.2: 4.5 h / 87 °C

2.1: acetonitrile / 3 h / 80 °C

3.1: ethanol / 6 h / 80 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

C₁₉H₂₁ClFN₅O₂*BrH

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline