6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline

Base Information

• Chemical Name: 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline
• CAS No.: 1360859-35-3
• Molecular Formula: C₁₉H₂₁ClFN₅O₂
• Molecular Weight: 405.859
• Mol file: 1360859-35-3.mol

Synonyms:6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline

Chemical Property of 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline

There total 6 articles about 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

6-(2-bromoethoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydroquinazolin-4-amine + ethylenediamine (107-15-3,85404-18-8) → 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline (1360859-35-3)

Guidance literature:

In acetonitrile; at 80 ℃; for 2.5h;

DOI:10.1039/c3cc43000f

Reference yield:

6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline (1360859-35-3)

Guidance literature:

Multi-step reaction with 4 steps

1: isopropyl alcohol / 3 h / Reflux

2: sodium methylate / methanol / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

4: acetonitrile / 2.5 h / Reflux

With sodium methylate; potassium carbonate; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1039/c5dt01430a

Reference yield:

RuIICl3(DMSO)(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline) (1373945-06-2) → 6-(2-(2-aminoethylamino)ethoxy)-4-(3-chloro-4-fluoro-phenylamino)-7-methoxy quinazoline (1360859-35-3) + RuIIICl2(DMSO)(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)(H2O)

Guidance literature:

With water; In dimethyl sulfoxide; at 36.84 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2014.02.062

upstream raw materials:

4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline

ethylenediamine

Ru^IICl₃(DMSO)(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

Downstream raw materials:

Ru^IICl₂(DMSO)2(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)

Ru^IICl₃(DMSO)(4-(3'-chloro-4'-fluoroanilino)-6-(2-(2-aminoethyl)aminoethoxy)-7-methoxyquinazoline)