(S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Base Information

• Chemical Name: (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate
• CAS No.: 949149-60-4
• Molecular Formula: C₂₀H₂₁NO₃
• Molecular Weight: 323.392
• Mol file: 949149-60-4.mol

Synonyms:(S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Chemical Property of (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

There total 3 articles about (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate + benzyl alcohol (100-51-6,185532-71-2) → (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate (949149-60-4) + benzyl (R)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Guidance literature:

With pyridinium p-toluenesulfonate; In toluene; for 24h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2017.04.005

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate (949149-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 100 °C

2: 97 percent / APTS / toluene / 18 h / Heating

With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In methanol; toluene;

DOI:10.1016/j.tetlet.2007.06.106

Reference yield:

Dimethyl itakonate (617-52-7) → (S)-benzyl-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate (949149-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 100 °C

2: 97 percent / APTS / toluene / 18 h / Heating

With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In methanol; toluene;

DOI:10.1016/j.tetlet.2007.06.106

upstream raw materials:

(R)-1-phenyl-ethyl-amine

Dimethyl itakonate

benzyl alcohol

Downstream raw materials:

(+)-(S)-3-carbamidopyrrolidine-1-carboxylic acid benzyl ester

(S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid

(S)-(+)-3-pyrrolidinecarboxylic acid

(3S)-benzyl-1-[(R)-1-phenylethyl]pyrrolidine-3-carboxylate