ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

Base Information

Chemical Name:ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate
CAS No.:1292849-95-6
Molecular Formula:C₃₀H₃₈Cl₂N₂O₄
Molecular Weight:561.549
Hs Code.:

Synonyms:ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

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Chemical Property of ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

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Technology Process of ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

There total 6 articles about ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₈ClNO₄

: 1292849-94-5
4-chloro-2-(2-chlorobenzyl)-N-(2,2-dimethylpropyl)-aniline

: 1292849-95-6
ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 737794-19-3
1-(3-carboxypropionyl)piperidine-4-carboxylic acid ethyl ester

: 1292849-95-6
ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / -15 °C

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-95-6
ethyl 1-(4-{[4-chloro-2-(2-chlorobenzyl)phenyl](2,2-dimethylpropyl)amino}-4-oxobutanoyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; acetic acid

2.1: trifluoromethylsulfonic anhydride; Triphenylphosphine oxide / dichloromethane / 2 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 °C

With dmap; sodium tetrahydroborate; trifluoromethylsulfonic anhydride; acetic acid; N-ethyl-N,N-diisopropylamine; Triphenylphosphine oxide; In dichloromethane;
DOI:10.1016/j.bmc.2011.01.065