74067-45-1

Basic information

• Product Name: Benzenemethanol, 2-amino-5-chloro-a-(2-chlorophenyl)-
• CAS NO: 74067-45-1
• Molecular Formula: C13H11Cl2NO
• Molecular Weight: 268.142
• Mol File: 74067-45-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-amino-5-chloro-a-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-amino-5-chloro-a-(2-chlorophenyl)-(74067-45-1)
• EPA Substance Registry System: Benzenemethanol, 2-amino-5-chloro-a-(2-chlorophenyl)-(74067-45-1)

Safety Data

• Hazardous Substances Data: 74067-45-1(Hazardous Substances Data)

Upstream product

• 77792-52-0 5-chloro-3-(2-chlorophenyl)-2,1-benzisoxazole 
• 100-00-5 4-chlorobenzonitrile 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 2856-63-5 2-Chlorophenylacetonitrile 

Downstream Products

• 106898-85-5 (2-Benzylamino-5-chloro-phenyl)-(2-chloro-phenyl)-methanol 
• 152912-11-3 cyclopropanecarboxylic acid {4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-amide 
• 152906-47-3 (E)-3-({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-cyclohexylmethyl-carbamoyl)-acrylic acid ethyl ester 
• 152906-98-4 (E)-3-[{4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(2-ethyl-butyl)-carbamoyl]-acrylic acid ethyl ester 
• 152910-50-4 (E)-3-[{4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(3,3-dimethyl-butyl)-carbamoyl]-acrylic acid ethyl ester 
• 152907-00-1 (E)-3-[{4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(3-methyl-butyl)-carbamoyl]-acrylic acid ethyl ester 
• 152910-49-1 (E)-3-({4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-cyclopropylmethyl-carbamoyl)-acrylic acid ethyl ester 
• 204502-82-9 (E)-3-(Butyl-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-carbamoyl)-acrylic acid ethyl ester 
• 152907-03-4 (E)-3-[{4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(1-ethyl-propyl)-carbamoyl]-acrylic acid ethyl ester 

Relevant articles and documents

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds. Further chemical modification led to the discovery of a novel template with a strong squalene synthase inhibitory activity, and its basic structure-activity relationship was revealed. The X-ray crystallographic data of compound 12 bound to the active site of squalene synthase provided an important insight into the binding mode of this alternative template that formed 11-membered ring conformations with an intramolecular hydrogen bond.

SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

ANNELATED QUINOLINE DERIVATIVES AS PESTICIDE

The invention relates to the use of quinoline derivatives of formula (I), where the dotted bond is either a single- or double-bond and the substituents have the meaning given in the description, as plant treatment agents, in particular, for the prevention