2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Base Information

Chemical Name:2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione
CAS No.:1197396-83-0
Molecular Formula:C₂₄H₂₈FN₅O₂
Molecular Weight:437.517
Hs Code.:

Synonyms:2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

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Chemical Property of 2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

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Technology Process of 2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

There total 13 articles about 2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₆FN₅O₂

: 1197396-83-0
2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: C₂₄H₂₆FN₅O₂; With sodium tris(acetoxy)borohydride; In methanol; dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In methanol; dichloromethane; water;

Reference yield:

: 757186-96-2
2-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,3-propanediol

: 1197396-83-0
2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / 20 °C / Inert atmosphere

1.2: 0.33 h

2.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; water / 18 h / 20 °C / 760.05 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 0 - 20 °C

5.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

6.2: pH ~ 8

7.1: triethylamine / chloroform / 4.5 h / Reflux; Inert atmosphere

8.1: pyridine / acetonitrile / 50 - 90 °C / Reflux; Inert atmosphere

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

10.1: ammonia / methanol; water

11.1: magnesium sulfate / methanol; dichloromethane / 2 h / 20 °C

12.1: sodium tris(acetoxy)borohydride / methanol; dichloromethane / 20 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; magnesium sulfate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 1197396-83-0
2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione

Guidance literature:: Multi-step reaction with 13 steps

1.1: ethanol / 3 h / Inert atmosphere; Reflux

2.1: toluene-4-sulfonic acid / 20 °C / Inert atmosphere

2.2: 0.33 h

3.1: hydrogen / palladium 10% on activated carbon / 1,4-dioxane; water / 18 h / 20 °C / 760.05 Torr

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

5.2: 0 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

7.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

7.2: pH ~ 8

8.1: triethylamine / chloroform / 4.5 h / Reflux; Inert atmosphere

9.1: pyridine / acetonitrile / 50 - 90 °C / Reflux; Inert atmosphere

10.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

11.1: ammonia / methanol; water

12.1: magnesium sulfate / methanol; dichloromethane / 2 h / 20 °C

13.1: sodium tris(acetoxy)borohydride / methanol; dichloromethane / 20 °C

With pyridine; hydrogenchloride; manganese(IV) oxide; ammonia; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; magnesium sulfate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;