METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

Base Information

• Chemical Name: METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
• CAS No.: 98827-44-2
• Molecular Formula: C8H7NO5S2
• Molecular Weight: 261.279
• Hs Code.: 2934991000
• Mol file: 98827-44-2.mol

Synonyms:Methyl 4-hydroxy-1,1-dioxo-2H-thiopheno[2,3-e]1,2-thiazine-3-carboxylate;

Chemical Property of METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

Chemical Property:

• Vapor Pressure: 2.04E-09mmHg at 25°C
• Refractive Index: 1.667
• Boiling Point: 464.2 °C at 760 mmHg
• Flash Point: 234.6 °C
• PSA: 129.32000
• Density: 1.716 g/cm³
• LogP: 1.84920

Purity/Quality:

99% ^*data from raw suppliers

Methyl 4-hydroxy-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE

There total 7 articles about METHYL 4-HYDROXY-2H-THIENO[2,3-E]-1,2-THIAZINE-3-CARBOXYLATE-1,1-DIOXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C9H13NO6S2 → methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide (98827-44-2)

Guidance literature:

With sodium methylate; In methanol; for 2h; Reflux; Large scale;

Reference yield: 79.0%

methyl 3-<<<(methoxcarbonyl)methyl>amino>sulfonyl>-2-thiophenecarboxylate (106820-63-7) → methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide (98827-44-2)

Guidance literature:

With sodium methylate; In methanol; for 2h; Concentration; Temperature; Reflux;

Reference yield:

(1,1,3-Trioxo-1,3-dihydro-1λ6-thieno[2,3-d]isothiazol-2-yl)-acetic acid methyl ester (1028285-17-7) → methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide (98827-44-2)

Guidance literature:

With methanol; sodium methylate; In toluene; at 80 ℃; for 4h;

DOI:10.1021/jm9607010

upstream raw materials:

methyl 3-<<<(methoxcarbonyl)methyl>amino>sulfonyl>-2-thiophenecarboxylate

(1,1,3-Trioxo-1,3-dihydro-1λ⁶-thieno[2,3-d]isothiazol-2-yl)-acetic acid methyl ester

2,3-dihydro-3-oxo-thieno<2,3-d>isothiazole-1,1-dioxide

3-chlorothiophene-2-carboxylic acid

Downstream raw materials:

methyl 4-hydroxy-2-<(4-methoxyphenyl)methyl>-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide

4-hydroxy-3-methoxycarbonyl-2-methyl-2H-thieno[2,3-e]-1,2-thiazine,1,1-dioxide

4-hydroxy-2-methyl-N-phenyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide

tenoxicam