106820-63-7

Basic information

• Product Name: Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate
• Synonyms: 3-[(2-methoxy-2-oxoethy) amino] sulphonyl-2-thiophene carboxylic acid methyl est;Methyl-3-SulfonylAminoMethylAcetate-2-ThiopheneCarboxylate;Methyl3-({[(methoxcarbonyl)methyl]amino}sulfonyl)-2-thiophenecarboxylate;METHYL3-{[(2-METHOXY-2-OXOETHYL)AMINO]SULFONYL}THIOPHENE-2-CARBOXYLATE;Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate;Methyl-N-(methoxycarbonylmethyl)-3-sulfamoylthiophene-2-carboxylate;3-[(2-METHOXY-2-OXOETHYL)AMINO]SULPHONYL-2-THIOPHENECARBOXYLICACID,METHYLESTER:3--2-MF:C9H11NO6S2;Methyl C3-sulfonyl amino methyl acetate C2-thiophene carboxylate
• CAS NO: 106820-63-7
• Molecular Formula: C9H11NO6S2
• Molecular Weight: 293.32
• EINECS: 1533716-785-6
• Product Categories: INTERMEDIATESOFTENOXICAM;Esters;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 106820-63-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 96-98°C
• Boiling Point: 452.3 °C at 760 mmHg
• Flash Point: 227.4 °C
• Appearance: /
• Density: 1.438 g/cm³
• Vapor Pressure: 2.27E-08mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.24±0.50(Predicted)
• CAS DataBase Reference: Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate(106820-63-7)
• EPA Substance Registry System: Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate(106820-63-7)

Safety Data

• Hazardous Substances Data: 106820-63-7(Hazardous Substances Data)

Usage

General Description

Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate is a chemical compound with the molecular formula C11H13NO5S. It is a thiophene derivative that contains a sulfamoyl group and a methyl ester group. Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including its antimicrobial and anti-inflammatory properties. Methyl 3-[(methoxycarbonylmethyl)sulfamoyl]thiophene-2-carboxylate is a versatile intermediate in organic synthesis and has shown promise for various applications in the field of medicinal chemistry.

InChI:InChI=1/C9H11NO6S2/c1-15-7(11)5-10-18(13,14)6-3-4-17-8(6)9(12)16-2/h3-4,10H,5H2,1-2H3

Upstream product

• 59337-91-6 3-chlorosulfonyl-thiophene-2-carboxylic acid chloride 
• 59337-89-2 3-chlorothiophene-2-carboxylic acid 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 

Downstream Products

• 59804-25-0 4-hydroxy-3-methoxycarbonyl-2-methyl-2H-thieno[2,3-e]-1,2-thiazine,1,1-dioxide 
• 106820-69-3 4-Hydroxy-2-(4-methoxy-benzyl)-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[2,3-e][1,2]thiazine-3-carboxylic acid pyridin-2-ylamide 
• 106820-61-5 methyl 4-hydroxy-2-<(4-methoxyphenyl)methyl>-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide 
• 59804-42-1 N-(3-chlorophenyl)-4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide 
• 59804-40-9 4-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[2,3-e][1,2]thiazine-3-carboxylic acid 4-hydroxy-anilide 
• 59804-41-0 4-hydroxy-N-(3-methylphenyl)-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide 
• 59804-37-4 tenoxicam 
• 59804-36-3 4-hydroxy-2-methyl-N-phenyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide 
• 98827-44-2 methyl 4-hydroxy-2H-thieno<2,3-e>-1,2-thiazine-3-carboxylate 1,1-dioxide 

Relevant articles and documents

5-aminothiazole non-steroidal anti-inflammatory compound as well as preparation method and application thereof

The invention discloses a 5-aminothiazole non-steroidal anti-inflammatory compound. The compound which is efficient, low in toxicity and small in side effect is prepared from an ester intermediate containing a thiazine ring and a 5-aminothiazole derivative through a transesterification reaction. The preparation method of the compound is simple, the compound has the active groups of the existing non-steroidal anti-inflammatory medicine; meanwhile, the special change of the nitrogen atom position is also designed; compared with the existing non-steroidal anti-inflammatory medicines, the compoundhas better anti-inflammatory and analgesic effects, particularly has good curative effects on arthritis, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, soft tissue inflammation and thelike, has small toxic and side effects on human bodies, and has a very wide market prospect.

Analogues and Derivatives of Tenoxicam. 1. Synthesis and Antiinflammatory Activity of Analogues with Different Residues on the Ring Nitrogen and the Amide Nitrogen

The synthesis of tenoxicam, 4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno-1,2-thiazine-3-carboxamide 1,1-dioxide (1e), and of the analogues with various residues on the ring nitrogen and the amide nitrogen is described.This new class of "oxicams" has pronounced antiinflammatory and analgesic properties.The very specific structure-activity relationship of isomeric and isosteric groups at the amide nitrogen has been evaluated.The substituent in position 2 also has a great influence on the pharmacological properties.Tenoxicam is presently underrgoing clinical trials.