(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Base Information

Chemical Name:(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester
CAS No.:113850-72-9
Molecular Formula:C₁₅H₁₉I₂NO₅
Molecular Weight:547.129
Hs Code.:

Synonyms:(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

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Chemical Property of (R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Chemical Property:

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Technology Process of (R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

There total 7 articles about (R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 173383-08-9
N-α-tert-butoxycarbonyl-4′-hydroxy-3′,5′-diiodo-D-phenylglycine

: 18107-18-1
diazomethyl-trimethyl-silane

: 113850-72-9
(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: In methanol; benzene; for 2.5h;
DOI:10.1248/cpb.53.1277

Reference yield: 95.0%

: 872877-06-0
(R)-N-tert-butoxycarbonyl-4'-hydroxy-3',5'-diiodophenylglycine methyl ester

: 74-88-4
methyl iodide

: 113850-72-9
(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: With potassium carbonate; In acetone; for 3h; Reflux;
DOI:10.1016/j.polymer.2011.06.010

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 113850-72-9
(R)-N-tert-butoxycarbonyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / methanol / 0 - 20 °C

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0 - 20 °C

3.1: sodium periodate; sodium chloride / water; acetic acid / 0.25 h

3.2: 6 h / 0 - 40 °C

4.1: potassium carbonate / acetone / 3 h / Reflux

With sodium periodate; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; sodium chloride; In 1,4-dioxane; methanol; water; acetic acid; acetone;
DOI:10.1016/j.polymer.2011.06.010