tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

Base Information

• Chemical Name: tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
• CAS No.: 1426689-05-5
• Molecular Formula: C₂₃H₂₄BrFN₂O₃
• Molecular Weight: 475.358
• Mol file: 1426689-05-5.mol

Synonyms:tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

Chemical Property of tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

There total 1 articles about tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-fluorobenzyl bromide (76283-09-5) + tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate (205383-87-5) → tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate (1426689-05-5)

Guidance literature:

With potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmcl.2013.01.017

Reference yield:

tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate (1426689-05-5) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → C27H29FN4O3 (1426688-88-1)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water; at 160 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

Reference yield:

tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate (1426689-05-5) → C29H33FN4O3 (1426689-19-1)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water; at 160 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2013.01.017

upstream raw materials:

4-bromo-2-fluorobenzyl bromide

tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate

Downstream raw materials:

1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

C₂₃H₂₃FN₄O

C₂₃H₂₀F₄N₄O

C₂₃H₂₃FN₄O