1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Base Information

Chemical Name:1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one
CAS No.:1426688-71-2
Molecular Formula:C₂₂H₂₁FN₄O
Molecular Weight:376.433
Hs Code.:

Synonyms:1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

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Chemical Property of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

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Technology Process of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

There total 4 articles about 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426688-88-1
C₂₇H₂₉FN₄O₃

: 1426688-71-2
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: at 0 - 20 ℃; Acidic conditions;
DOI:10.1016/j.bmcl.2013.01.017

Reference yield:

: 1426689-05-5
tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

: 1426688-71-2
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C

2: 0 - 20 °C / Acidic conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.01.017

Reference yield:

: 205383-87-5
tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate

: 1426688-71-2
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C

3: 0 - 20 °C / Acidic conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.01.017