(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Base Information

Chemical Name:(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide
CAS No.:172476-78-7
Molecular Formula:C₁₃H₁₅NO₄
Molecular Weight:249.266
Hs Code.:

Synonyms:(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Suppliers and Price of (R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Chemical Property:

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Technology Process of (R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

There total 3 articles about (R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (R)-Hydroxy-phenyl-acetic acid (1S,5R)-5-hydroxyamino-cyclopent-2-enyl ester; hydrochloride

: 172476-78-7
(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Guidance literature:: With sodium hydrogencarbonate; In water;
DOI:10.1016/0040-4039(95)01525-6

Reference yield:

: 126924-19-4
(2R)-(-)-2-hydroxy-2-phenylacetohydroxamic acid

: 172476-78-7
(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / Et₄NIO₄ / methanol / -78 °C

2: 98 percent / hydrochloric acid / dioxane; H₂O / 3.5 h / Ambient temperature

3: 89 percent / sodium hydrogen carbonate / H₂O

With hydrogenchloride; sodium hydrogencarbonate; tetraethylammonium metaperiodate; In 1,4-dioxane; methanol; water;
DOI:10.1016/0040-4039(95)01525-6

Reference yield:

: 126924-22-9
(1S,4R,αR-)-3-(α-hydroxyphenylacetyl)-2-oxa-3-aza-bicyclo[2,2,1]hept-5-ene

: 172476-78-7
(R)-2,N-Dihydroxy-N-((1R,2S)-2-hydroxy-cyclopent-3-enyl)-2-phenyl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / hydrochloric acid / dioxane; H₂O / 3.5 h / Ambient temperature

2: 89 percent / sodium hydrogen carbonate / H₂O

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1016/0040-4039(95)01525-6