methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate

Base Information

• Chemical Name: methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate
• CAS No.: 1190427-73-6
• Molecular Formula: C₁₈H₂₀INO₃
• Molecular Weight: 425.266
• Mol file: 1190427-73-6.mol

Synonyms:methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate

Chemical Property of methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate

There total 1 articles about methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-[1-(2-iodophenyl)ethyl]-4-methoxyaniline (1245604-74-3) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate (1190427-73-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 24h; Reflux;

DOI:10.1021/jo101054j

Reference yield: 98.0%

methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate (1190427-73-6) → methyl 2-(4-methoxyphenyl)-3-methylisoindoline-1-carboxylate (1245604-26-5)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 110 ℃; for 48h;

DOI:10.1021/jo101054j

Reference yield: 40.0%

methyl 2-(N-[1-(2-iodophenyl)ethyl]-N-(4-methoxyphenyl)amino)acetate (1190427-73-6) → methyl 2-(4-methoxyphenyl)-3-methyl-2H-isoindole-1-carboxylate (1000774-85-5)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenol; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

DOI:10.1021/jo101054j

upstream raw materials:

N-[1-(2-iodophenyl)ethyl]-4-methoxyaniline

bromoacetic acid methyl ester

Downstream raw materials:

methyl 2-(4-methoxyphenyl)-3-methyl-2H-isoindole-1-carboxylate

methyl 2-(4-methoxyphenyl)-3-methylisoindoline-1-carboxylate