2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

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Chemical Name:2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone
CAS No.:1380427-54-2
Molecular Formula:C₂₈H₂₁ClF₃N₃O₂S
Molecular Weight:556.008
Hs Code.:

Synonyms:2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

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Chemical Property of 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

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Technology Process of 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

There total 3 articles about 2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.75%

: 1369255-78-6
1-chloro-4-(4-(chloromethyl)phenoxy)-2-(trifluoromethyl)benzene

: 1380430-62-5
5-[(1-methyl-1H-indol-3-yl)methyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

: 1380427-54-2
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 516481-95-1
4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde

: 1380427-54-2
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate / 20 °C

2: thionyl chloride / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With methanol; sodium tetrahydroborate; thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6294-93-5
4-chloro-3-trifluoromethylphenol

: 1380427-54-2
2-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-5-[(1-methyl-1H-indol-3-yl)methyl]-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

2: methanol; sodium tetrahydroborate / 20 °C

3: thionyl chloride / dichloromethane / 1.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With methanol; sodium tetrahydroborate; thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;