1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

Base Information

Chemical Name:1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea
CAS No.:1362852-54-7
Molecular Formula:C₂₂H₂₂ClN₅O₂
Molecular Weight:425.886
Hs Code.:

Synonyms:1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

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Chemical Property of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

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Technology Process of 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

There total 13 articles about 1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1362855-49-9
C₂₇H₂₈⁽²⁾H₂ClN₅O₄

: 1362852-54-7
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

Guidance literature:: C₂₇H₂₈⁽²⁾H₂ClN₅O₄; With trifluoroacetic acid; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; for 0.5h; pH=7 - 8;

Reference yield:

: 54221-95-3
2-(acetylamino)isonicotinic acid

: 1362852-54-7
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / ethanol / Reflux

2.1: tert-butyl alcohol / 16 h / 60 °C

3.1: calcium chloride; sodium borodeuteride / d⁽⁴⁾-methanol / 0 - 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

6.1: trifluoroacetic acid / 1 h / 20 °C

6.2: 0.5 h / pH 7 - 8

With sodium borodeuteride; carbon tetrabromide; boron trifluoride diethyl etherate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; calcium chloride; In ethanol; dichloromethane; d⁽⁴⁾-methanol; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1362855-33-1
C₁₁H₁₄⁽²⁾H₂N₂O₃

: 1362852-54-7
1-[1-[(2-amino-4-pyridyl)-dideuteriomethyl]indolin-4-yl]-3-(5-chloro-2-methoxyphenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3.1: trifluoroacetic acid / 1 h / 20 °C

3.2: 0.5 h / pH 7 - 8

With carbon tetrabromide; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;