2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

Base Information

Chemical Name:2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran
CAS No.:157555-34-5
Molecular Formula:C₂₀H₂₇ClO₂
Molecular Weight:334.886
Hs Code.:

Synonyms:2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

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Chemical Property of 2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

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Technology Process of 2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

There total 2 articles about 2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39225-17-7
diethyl 4-chlorobenzylphosphonate

: 157555-32-3
(R,S)-(1α,4β)-1-methyl-4-<(tetrahydro-2H-pyran-2-yl)oxy>cyclohexanecarboxaldehyde

: 157555-34-5
2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

Guidance literature:: With sodium methylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;
DOI:10.1021/jm00041a013

Reference yield:

: 87787-12-0
1-methyl-t-4-(2-tetrahydropyranyloxy)-r-1-cyclohexanemethanol

: 157555-34-5
2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / SO₃, pyridine, triethylamine / dimethylsulfoxide / 0.75 h / Ambient temperature

2: NaOMe / dimethylformamide / 0.25 h / 0 °C

With pyridine; sulfur trioxide; sodium methylate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a013

Reference yield:

: 157555-34-5
2-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-4-methyl-cyclohexyloxy}-tetrahydro-pyran

: 4-{2-[4-(5-Hydroxy-5-methyl-hexyl)-phenyl]-ethyl}-4-methyl-cyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: Ni(dppp)Cl₂ / diethyl ether; tetrahydrofuran / 22 h / 31 °C

2: aq. acetic acid / tetrahydrofuran / 29 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethanol / 3 h / 2068.6 Torr / Ambient temperature

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jm00041a013