(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Base Information

Chemical Name:(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
CAS No.:1441057-54-0
Molecular Formula:C₂₄H₂₁F₆N₅O₂
Molecular Weight:525.453
Hs Code.:

Synonyms:(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Property of (R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Technology Process of (R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

There total 10 articles about (R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441049-25-7
3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-54-0
(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With CHIRALPAK IA; In methanol; diethylamine;

Reference yield:

: 1441057-70-0
2,2,2-trifluoro-1-(4-(4,4,4-trifluoro-butoxy)phenyl)ethanol

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-54-0
(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

2: dimethyl sulfoxide / 160 °C / Microwave irradiation

3: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

4: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

5: piperidine / ethanol / 16 h / 78 °C / Sealed tube

6: CHIRALPAK? IA / methanol; diethylamine

With piperidine; ammonium hydroxide; Dess-Martin periodane; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; diethylamine;

Reference yield:

: 1441057-72-2
2,2,2-trifluoro-1-(4-(4,4,4-trifluoro-butoxy)phenyl)ethanone

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-54-0
(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 160 °C / Microwave irradiation

2: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

3: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

4: piperidine / ethanol / 16 h / 78 °C / Sealed tube

5: CHIRALPAK? IA / methanol; diethylamine

With piperidine; ammonium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; diethylamine;