(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Name:(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
CAS No.:1441057-15-3
Molecular Formula:C₂₄H₂₁F₆N₅O₂
Molecular Weight:525.453
Hs Code.:

Synonyms:(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Property of (S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Technology Process of (S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

There total 23 articles about (S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: (S)-2-(1H-Tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)phenyl)butan-2-yl)acetamide

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With piperidine; In ethanol; at 78 ℃;
DOI:10.1021/acs.jmedchem.1c01356

Reference yield:

: 1441049-25-7
3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

: 1441057-54-0
(R)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With CHIRALPAK IA; In methanol; diethylamine;

Reference yield:

: 1441057-81-3
3-amino-4,4,4-trifluoro-1-p-tolyl-3-(4-(4,4,4-trifluorobutoxy)phenyl)-butan-1-one

: 1441057-15-3
(S)-3-(1H-tetrazol-5-yl)-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: Chiralcel OD-H / methanol; carbon dioxide / Resolution of racemate; liquid CO₂

2: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

3: piperidine / ethanol / 78 °C

With piperidine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; carbon dioxide; 3: |Aldol Condensation;
DOI:10.1021/acs.jmedchem.1c01356