1H-Pyrazole-5-carboxamide,1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)
• CAS No.: 98711-43-4
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.13
• Hs Code.: 2933199090
• Mol file: 98711-43-4.mol

Synonyms:1H-Pyrazole-5-carboxamide,1-methyl-;

Chemical Property of 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)

Chemical Property:

• Vapor Pressure: 4.74E-05mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 349.324 °C at 760 mmHg
• Flash Point: 165.066 °C
• PSA: 60.91000
• Density: 1.346 g/cm³
• LogP: 0.21930

Purity/Quality:

98%Min ^*data from raw suppliers

1-methyl-1H-pyrazole-5-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxamide,1-methyl-(9CI)

There total 2 articles about 1H-Pyrazole-5-carboxamide,1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 1-methyl-1H-pyrazole-5-carboxylate (17827-60-0) → 2-methyl-2H-pyrazole-3-carboxylic acid amide (98711-43-4)

Guidance literature:

With ammonia; In water; for 16h;

Reference yield: 36.0%

1-methyl-1H-pyrazole-5-carboxylic acid (16034-46-1) → 2-methyl-2H-pyrazole-3-carboxylic acid amide (98711-43-4)

Guidance literature:

1-methyl-1H-pyrazole-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2h; Glovebox; Autoclave;

With ammonia; In tetrahydrofuran; at 20 ℃; for 2h; Autoclave; Cooling;

DOI:10.1021/acs.oprd.0c00437

Reference yield: 82.0%

tert-butyl 6-bromo-2-(o-tolyl)-1H-pyrrolo[3,2-b]pyridine-1-carboxylate + 2-methyl-2H-pyrazole-3-carboxylic acid amide (98711-43-4) → tert-butyl 6-(1-methyl-1H-pyrazole-5-carboxamido)-2-(o-tolyl)-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 110 ℃; for 2h; Inert atmosphere;

upstream raw materials:

methyl 1-methyl-1H-pyrazole-5-carboxylate

1-methyl-1H-pyrazole-5-carboxylic acid

Downstream raw materials:

C-(2-methyl-2H-pyrazol-3-yl)methyl amine