17827-60-0

Basic information

• Product Name: methyl 1-methyl-1H-pyrazole-5-carboxylate
• Synonyms: methyl 1-methyl-1H-pyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-Methyl-, Methyl ester;Methyl 2-Methylpyrazole-3-carboxylate;Pyrazole-5-carboxylic acid, 1-Methyl-, Methyl ester;2-methyl-3-pyrazolecarboxylic acid methyl ester;2-methylpyrazole-3-carboxylic acid methyl ester;Methyl 1-methylpyrazole-5-carboxylate;2-Methyl-2H-Pyrazole-3-Carboxylic Acid Methyl Ester(WX618160)
• CAS NO: 17827-60-0
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140
• Mol File: 17827-60-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 221.622 °C at 760 mmHg
• Flash Point: 87.834 °C
• Appearance: /
• Density: 1.188 g/cm³
• Storage Temp.: 2-8°C
• PKA: 0.47±0.10(Predicted)
• CAS DataBase Reference: methyl 1-methyl-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-methyl-1H-pyrazole-5-carboxylate(17827-60-0)
• EPA Substance Registry System: methyl 1-methyl-1H-pyrazole-5-carboxylate(17827-60-0)

Safety Data

• Hazardous Substances Data: 17827-60-0(Hazardous Substances Data)

Usage

General Description

Methyl 1-methyl-1H-pyrazole-5-carboxylate is a chemical compound with the molecular formula C7H8N2O2. It is a methyl ester derivative of 1-methyl-1H-pyrazole-5-carboxylic acid. This chemical is commonly used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. It is also known for its potential biological activities, such as its role as an inhibitor of histone deacetylase, an enzyme involved in gene regulation and protein function. Methyl 1-methyl-1H-pyrazole-5-carboxylate is a versatile compound with various industrial and research applications.

Upstream product

• 67-56-1 methanol 
• 696-22-0 5-methyl-2H-pyrazole-3-carboxylic acid 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 1621-91-6 1-2H-pyrazole-3-carboxylic acid 

Downstream Products

• 75092-26-1 4-iodo-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 84547-61-5 (1-methyl-1H-pyrazol-5-yl)methanol 
• 98711-43-4 2-methyl-2H-pyrazole-3-carboxylic acid amide 

Relevant articles and documents

FUSED AZOLE HETEROCYCLES AS AHR ANTAGONISTS

The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Secondary metabolites from the Gorgonian Echinomuraceae splendens (Thomson & Simson)

Two xanthine derivatives, caffeine (1, 3, 7-trimethylxanthine) 1 and its 2-O-methyl analog (Δ1, O2- methyl theobromine) 2, N-methyl-pyrazole-5-carboxylic acid 3 and a tetrahydroxy sterol, 1β, 3β, 5α, 6β-tetrahydroxycholestane 4 have been isolated from the methanol extract of the gorgonian Echinomuraceae spendens (Thomson & Simson). These compounds have been purified on silica gel and Sephadex LH-20 columns and their structures elucidated by spectroscopic studies. This is the first report of the occurrence of compounds 2 and 3 in nature. Caffeine exhibits mild antifouling activity against marine fouling organisms while its O-methyl analog 2 is inactive.