17827-60-0

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1-methyl-1H-pyrazole-5-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its role in inhibiting histone deacetylase makes it a valuable component in the development of drugs targeting gene regulation and protein function, which can have significant implications for the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 1-methyl-1H-pyrazole-5-carboxylate serves as an essential intermediate in the production of agrochemicals. Its chemical properties and reactivity contribute to the development of effective compounds for agricultural applications, such as pesticides and herbicides, enhancing crop protection and yield.
Used in Research Applications:
Methyl 1-methyl-1H-pyrazole-5-carboxylate is also employed in research settings for the investigation of its biological activities and potential applications. Its role as a histone deacetylase inhibitor makes it a subject of interest for studies exploring gene regulation, protein function, and the development of novel therapeutic agents.

Upstream product

• 67-56-1 methanol 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 696-22-0 5-methyl-2H-pyrazole-3-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 1621-91-6 1-2H-pyrazole-3-carboxylic acid 

Downstream Products

• 84547-61-5 (1-methyl-1H-pyrazol-5-yl)methanol 
• 75092-26-1 4-iodo-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 98711-43-4 2-methyl-2H-pyrazole-3-carboxylic acid amide 

Relevant academic research and scientific papers

GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes

GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated as a potential drug target of Huntington's disease (HD), an incurable monogenic neurodegenerative disorder. In this research, we found that striatal knockdown of GPR52 reduces mHTT levels in adult HdhQ140 mice, validating GPR52 as an HD target. In addition, we discovered a highly potent and specific GPR52 antagonist Comp-43 with an IC50 value of 0.63 μM by a structure-activity relationship (SAR) study. Further studies showed that Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Moreover, in vivo study showed that Comp-43 not only reduces mHTT levels but also rescues HD-related phenotypes in HdhQ140 mice. Taken together, our study confirms that inhibition of GPR52 is a promising strategy for HD therapy, and the GPR52 antagonist Comp-43 might serve as a lead compound for further investigation.

FUSED AZOLE HETEROCYCLES AS AHR ANTAGONISTS

The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

INHIBITORS OF HEPATITIS C VIRUS PROTEASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The present invention provides compounds of formula (I), (II) or (IV), or pharmaceutically acceptable salts and solvates thereof, which are useful as inhibitors of the Hepatitis C virus (HCV) protease enzyme and are also useful for the treatment of HCV infections in HCV--infected mammals, including humans. The present invention also provides pharmaceutical compositions comprising compounds of formula (I), (II) or (IV), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formulas (I), (II) and (IV).

Secondary metabolites from the Gorgonian Echinomuraceae splendens (Thomson & Simson)

Two xanthine derivatives, caffeine (1, 3, 7-trimethylxanthine) 1 and its 2-O-methyl analog (Δ1, O2- methyl theobromine) 2, N-methyl-pyrazole-5-carboxylic acid 3 and a tetrahydroxy sterol, 1β, 3β, 5α, 6β-tetrahydroxycholestane 4 have been isolated from the methanol extract of the gorgonian Echinomuraceae spendens (Thomson & Simson). These compounds have been purified on silica gel and Sephadex LH-20 columns and their structures elucidated by spectroscopic studies. This is the first report of the occurrence of compounds 2 and 3 in nature. Caffeine exhibits mild antifouling activity against marine fouling organisms while its O-methyl analog 2 is inactive.