5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile

Base Information

• Chemical Name: 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile
• CAS No.: 1310417-55-0
• Molecular Formula: C₁₇H₁₈N₄O₂
• Molecular Weight: 310.356

Synonyms:5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile

Chemical Property of 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile

Chemical Property:

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Technology Process of 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile

There total 3 articles about 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C24H24N4O2 (1310417-57-2) → 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile (1310417-55-0)

Guidance literature:

C₂₄H₂₄N₄O₂; With boron trichloride - methyl sulfide complex; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1111/j.1747-0285.2011.01113.x

Reference yield:

ethyl 2-ethyl-3-oxobutanoate (607-97-6) → 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile (1310417-55-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere

1.2: 0.17 h / Inert atmosphere

1.3: 2 h / Inert atmosphere

2.1: ethanol / 9 h / Inert atmosphere; Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere; Reflux

4.1: boron trichloride - methyl sulfide complex / dichloromethane / 0 - 20 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With boron trichloride - methyl sulfide complex; sodium hydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1111/j.1747-0285.2011.01113.x

Reference yield:

5-benzyloxy-3-oxo-2-ethyl-pentanoic acid ethyl ester (84572-73-6) → 5-[2,4-diethyl-5-(2-hydroxy-ethyl)-2H-pyrazol-3-yloxy]isophthalonitrile (1310417-55-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 9 h / Inert atmosphere; Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere; Reflux

3.1: boron trichloride - methyl sulfide complex / dichloromethane / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With boron trichloride - methyl sulfide complex; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1111/j.1747-0285.2011.01113.x

upstream raw materials:

C₂₄H₂₄N₄O₂

5-benzyloxy-3-oxo-2-ethyl-pentanoic acid ethyl ester

ethyl 2-ethyl-3-oxobutanoate

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