2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

Base Information

Chemical Name:2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile
CAS No.:1393809-83-0
Molecular Formula:C₃₃H₃₀BrClN₂O
Molecular Weight:585.971
Hs Code.:

Synonyms:2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

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Chemical Property of 2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

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Technology Process of 2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

There total 3 articles about 2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1393809-81-8
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-hydroxy-3-(trityloxy)propan-2-yl)amino)acetonitrile

: 1393809-83-0
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

Guidance literature:: With pyridine; thionyl chloride; In dichloromethane; at 0 ℃; for 0.416667h; Inert atmosphere;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-78-3
2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

: 1393809-83-0
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: pyridine; thionyl chloride / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

With pyridine; thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-77-2
C₁₂H₁₆BrNO₂

: 1393809-83-0
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-chloro-3-(trityloxy)propan-2-yl)amino)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / 85 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C

3: pyridine; thionyl chloride / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

With pyridine; thionyl chloride; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jo300974j