2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

Base Information

Chemical Name:2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile
CAS No.:1393809-78-3
Molecular Formula:C₁₄H₁₇BrN₂O₂
Molecular Weight:325.205
Hs Code.:

Synonyms:2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

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Chemical Property of 2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

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Technology Process of 2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

There total 1 articles about 2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1393809-77-2
C₁₂H₁₆BrNO₂

: 590-17-0
cyanomethyl bromide

: 1393809-78-3
2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo300974j

Reference yield: 97.0%

: 1393809-78-3
2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

: 76-83-5
trityl chloride

: 1393809-81-8
2-(allyl((1S,2R)-1-(4-bromophenyl)-1-hydroxy-3-(trityloxy)propan-2-yl)amino)acetonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo300974j

Reference yield:

: 1393809-78-3
2-(allyl((1S,2R)-1-(4-bromophenyl)-1,3-dihydroxypropan-2-yl)amino)acetonitrile

: C₂₁H₂₂BrN₃O₅S

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: pyridine; thionyl chloride / dichloromethane / 0.42 h / 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

7.1: Grubbs catalyst first generation / benzene / 24 h / 50 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 0 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; Grubbs catalyst first generation; thionyl chloride; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo300974j