Z-SER(BZL)-OSU

Base Information

• Chemical Name: Z-SER(BZL)-OSU
• CAS No.: 98647-23-5
• Molecular Formula: C22H22 N2 O7
• Molecular Weight: 426.42
• Mol file: 98647-23-5.mol

Synonyms:Carbamicacid, [2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-,phenylmethyl ester, (S)-

Chemical Property of Z-SER(BZL)-OSU

Chemical Property:

• PSA: 111.24000
• LogP: 2.43420
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-O-benzyl-L-serine N-hydroxysuccinimide ester 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-SER(BZL)-OSU

There total 4 articles about Z-SER(BZL)-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Z-Ser(Bzl)-OH (20806-43-3) → O-benzyl-Nα-benzyloxycarbonylserine succinimidyl ester (98647-23-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; Yield given; 1.) 0 deg C, 1 h; 2.) RT;

DOI:10.1016/S0040-4020(01)96557-3

Reference yield:

O-Benzyl-L-serine (4726-96-9,32520-12-0) → O-benzyl-Nα-benzyloxycarbonylserine succinimidyl ester (98647-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / Et₃N / dioxane; methanol / 1 h

2: dicyclohexylcarbodiimide / dioxane / 1 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4020(99)00177-5

Reference yield:

N-(benzyloxycarbonyl)succinimide (75315-63-8) → O-benzyl-Nα-benzyloxycarbonylserine succinimidyl ester (98647-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / Et₃N / dioxane; methanol / 1 h

2: dicyclohexylcarbodiimide / dioxane / 1 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol;

DOI:10.1016/S0040-4020(99)00177-5

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Z-Ser(Bzl)-OH

O-Benzyl-L-serine

N-(benzyloxycarbonyl)succinimide

Downstream raw materials:

(R)-2-benzyloxycarbonylamino-1-benzyloxymethyl-4-aminopropane

(R)-2-Benzyloxymethyl-4-(3,4,5-trimethoxy-benzoyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

{(R)-2-Benzyloxy-1-[(2,2-diethoxy-ethylamino)-methyl]-ethyl}-carbamic acid benzyl ester

Methanesulfonic acid (S)-3-benzyloxy-2-benzyloxycarbonylamino-propyl ester