2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide

Base Information

• Chemical Name: 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide
• CAS No.: 137550-67-5
• Molecular Formula: C₁₂H₇F₆NO₃
• Molecular Weight: 327.183
• Mol file: 137550-67-5.mol

Synonyms:2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide

Chemical Property of 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide

There total 3 articles about 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

trifluoroacetic acid-methyl ester (431-47-0) + 1-(3-aminophenyl)ethanone (99-03-6) → 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide (137550-67-5)

Guidance literature:

With sodium hydride; In diethyl ether; at 25 - 100 ℃; for 3h; Inert atmosphere;

DOI:10.1134/S1070363213030110

Reference yield: 78.0%

trifluoroacetic acid-methyl ester (431-47-0) + 3-trifluoroacetamidoacetophenone (56915-87-8) → 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide (137550-67-5)

Guidance literature:

With sodium hydride; In diethyl ether; for 3h;

DOI:10.1134/S107036321205012X

Reference yield:

ethyl trifluoroacetate, (383-63-1) + 3-trifluoroacetamidoacetophenone (56915-87-8) → 2,2,2-trifluoro-N-(3-(4,4,4-trifluoro-3-oxobutanoyl)phenyl)acetamide (137550-67-5)

Guidance literature:

3-trifluoroacetamidoacetophenone; With sodium hydride; In tetrahydrofuran;

ethyl trifluoroacetate,; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.bmc.2018.05.012

upstream raw materials:

trifluoroacetic acid-methyl ester

3-trifluoroacetamidoacetophenone

1-(3-aminophenyl)ethanone

ethyl trifluoroacetate,

Downstream raw materials:

3-trifluoroacetamidoacetophenone

1-(3-aminophenyl)ethanone