4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI)

Base Information

• Chemical Name: 4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI)
• CAS No.: 98598-86-8
• Molecular Formula: C₆H₅FN₂O
• Molecular Weight: 140.117
• Mol file: 98598-86-8.mol

Synonyms:4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI)

Chemical Property of 4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI)

There total 5 articles about 4-Pyridinecarboxaldehyde,3-fluoro-,oxime,(E)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-fluoropyridine-4-carbaldehyde (40273-47-0) → 3-fluoroisonicotinaldehyde oxime (471909-36-1,98598-86-8)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmcl.2008.12.070

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 3-fluoroisonicotinaldehyde oxime (471909-36-1,98598-86-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid

2: tetrafluoroboric acid; ethyl nitrite

3: iodine; potassium acetate / acetic anhydride

4: ozone

5: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 0.33 h / 60 °C

With tetrafluoroboric acid; ethyl nitrite; sulfuric acid; hydroxylamine hydrochloride; iodine; nitric acid; potassium acetate; ozone; sodium hydroxide; In ethanol; water; acetic anhydride; 2: Balz-Schiemann reaction;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

3-fluoro-4-methylpyridine (399-88-2) → 3-fluoroisonicotinaldehyde oxime (471909-36-1,98598-86-8)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; potassium acetate / acetic anhydride

2: ozone

3: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 0.33 h / 60 °C

With hydroxylamine hydrochloride; iodine; potassium acetate; ozone; sodium hydroxide; In ethanol; water; acetic anhydride;

DOI:10.1016/j.jfluchem.2011.05.028

upstream raw materials:

3-fluoropyridine-4-carbaldehyde

2-Amino-4-methylpyridine

3-fluoro-4-methylpyridine

3-amino-4-methylpyridine

Refernces

• 1、 Timperley, Christopher M.,Banks, R. Eric,Young, Ian M.,Haszeldine, Robert N.. "Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning". experimental part. p. 541 - 547. Retrieved 2011/09/15.