399-88-2

Basic information

• Product Name: 3-Fluoro-4-methylpyridine
• Synonyms: 3-FLUORO-4-PICOLINE;3-FLUORO-4-METHYLPYRIDINE;3-FLUORO-4-METHYLPYRIDINE (3-FLUORO-4-PICOLINE);4-METHYL-3-FLUOROPYRIDINE;2-fluo-3-methylpyridine;Pyridine, 3-fluoro-4-methyl-;3-Fluoro-4-methylpyridin
• CAS NO: 399-88-2
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.12
• EINECS: 1312995-182-4
• Product Categories: Fluorin-contained pyridine series;Pyridine;Pyridines
• Mol File: 399-88-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 135,6 C
• Flash Point: 34.3 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.08 g/cm
• Refractive Index: 1,479
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.48±0.18(Predicted)
• CAS DataBase Reference: 3-Fluoro-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-methylpyridine(399-88-2)
• EPA Substance Registry System: 3-Fluoro-4-methylpyridine(399-88-2)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 399-88-2(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-methylpyridine is a chemical compound with the molecular formula C6H6FN. It is a flammable, colorless liquid with a strong odor. 3-Fluoro-4-methylpyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of other organic compounds, such as pesticides and insecticides. 3-Fluoro-4-methylpyridine is considered to have low to moderate toxicity, with potential health hazards including skin and eye irritation, as well as harmful effects if ingested or inhaled. It is important to handle and store this chemical with care, following safety guidelines and regulations.

Upstream product

• 3430-27-1 3-amino-4-methylpyridine 
• 372-47-4 3-Fluoropyridine 
• 74-88-4 methyl iodide 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 6635-86-5 2-amino-4-methyl-3-nitropyridine 
• 21901-18-8 2-hydroxy-4-methyl-3-nitropyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 393-53-3 3-fluoroisonicotinic acid 
• 33252-59-4 3-fluoro-4-methylpyridine-N-oxide 
• 312904-99-7 2-cyano-3-fluoro-4-methylpyridine 
• 343-72-6 ethyl 3-fluoroisonicotinate 
• 471909-36-1 3-fluoroisonicotinaldehyde oxime 
• 40273-47-0 3-fluoropyridine-4-carbaldehyde 
• 177600-62-3 C₁₃H₁₀FN 
• 1383377-54-5 1-(4-fluorophenyl)-2-(3-fluoropyridin-4-yl)ethanone 
• 1260878-78-1 4-chloro-3-fluoro-2-formylpyridine 
• 1417554-27-8 C₁₀H₁₀BrFN₂O₅ 
• 1417554-26-7 C₆H₄BrFN₂O₃ 
• 1417554-25-6 C₆H₅FN₂O₃ 
• 1417529-73-7 C₆H₆FNO 
• 1417556-12-7 C₈H₈FNO₂ 

Relevant articles and documents

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright

PYRIDINE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR TREATING DISEASES RELATED TO MCH RECEPTOR

The present invention encompasses novel substituted pyridine compounds of Formula (I), which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: A is ?wherein Y1and Y2are independently hydrogen, C1-4alkyl, C1-4alkoxy, FuHvC(CH2)0-1O—, wherein u and v are either 1 or 2, provided that when u is 1, v is 2, and when u is 2, v is 1, C3-7cycloalkyl, thio C1-4alkyl, C1-4sulfinylalkyl, C1-4sulfonylalkyl, halogen cyano, or trifluoromethyl, and wherein b is 0 or 1.