3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

Base Information

Chemical Name:3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol
CAS No.:719293-96-6
Molecular Formula:C₂₀H₂₀F₆O₂S
Molecular Weight:438.434
Hs Code.:

Synonyms:3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

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Chemical Property of 3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

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Technology Process of 3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

There total 7 articles about 3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 719294-00-5
3-{4-[4-(2-carboxy-ethyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propionic acid

: 719293-96-6
3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

Guidance literature:: 3-{4-[4-(2-carboxy-ethyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propionic acid; With sodium tetrahydroborate; In tetrahydrofuran; for 0.5h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 48h;

Reference yield:

: 393-19-1
2,2'-bis(trifluoromethyl)-4,4'-diaminodiphenyl sulfide

: 719293-96-6
3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 9 h / 110 °C / Heating / reflux

3.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

4.1: sodium periodate; hydrazine / ethanol; water / 5 h / 20 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h

5.2: 48 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium periodate; water; triethylamine; hydrazine; sodium nitrite; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); ethanol; water;

Reference yield:

: 719293-97-7
4,4'-diiodo-2,2'-bis(trifluoromethyl)diphenylsulfide

: 719293-96-6
3-{4-[4-(3-hydroxy-propyl)-2-trifluoromethyl-phenylsulfanyl]-3-trifluoromethyl-phenyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / DMF (N,N-dimethyl-formamide) / 9 h / 110 °C / Heating / reflux

2.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

3.1: sodium periodate; hydrazine / ethanol; water / 5 h / 20 °C

4.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h

4.2: 48 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; sodium periodate; water; triethylamine; hydrazine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); ethanol; water;