(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

Base Information

Chemical Name:(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one
CAS No.:334968-79-5
Molecular Formula:C₁₇H₂₁NO₃S
Molecular Weight:319.425
Hs Code.:

Synonyms:(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

Suppliers and Price of (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

There total 1 articles about (2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 7319-38-2
3-butenal

: 334968-78-4
(R)-1-(4-benzyl-2-thioxooxazolidin-3-yl)propan-1-one

: 334968-79-5
(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

Guidance literature:: With titanium tetrachloride; (-)-sparteine; In dichloromethane; at -78 - 0 ℃;
DOI:10.1021/ol015652m

Reference yield:

: 334968-79-5
(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

: 334968-84-2
(S)-Benzyloxy-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-acetaldehyde

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-lutidine

2: NaBH₄ / methanol; diethyl ether

3: Dess-Martin periodinane

4: 74 percent / Bu₂BOTf; DIPEA / CH₂Cl₂ / -78 °C

5: LiBH₄ / methanol; diethyl ether

6: Et₃N; DMAP

7: OsO₄; NaIO₄

8: POCl₃; pyridine / 70 °C

9: i-Bu₂AlH

10: Dess-Martin periodinane

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diethyl ether; dichloromethane; 3: Dess-Martin oxidation / 10: Dess-Martin oxidation;
DOI:10.1021/ol015652m

Reference yield:

: 334968-79-5
(2R,3S)-1-((R)-4-Benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-2-methyl-hex-5-en-1-one

: 334968-75-1
(S)-1-Benzyloxy-1-[(2R,3S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-3,4-dihydro-2H-pyran-2-yl]-propan-2-one

Guidance literature:: Multi-step reaction with 12 steps

1: 2,6-lutidine

2: NaBH₄ / methanol; diethyl ether

3: Dess-Martin periodinane

4: 74 percent / Bu₂BOTf; DIPEA / CH₂Cl₂ / -78 °C

5: LiBH₄ / methanol; diethyl ether

6: Et₃N; DMAP

7: OsO₄; NaIO₄

8: POCl₃; pyridine / 70 °C

9: i-Bu₂AlH

10: Dess-Martin periodinane

11: diethyl ether

12: Dess-Martin periodinane

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diethyl ether; dichloromethane; 3: Dess-Martin oxidation / 10: Dess-Martin oxidation / 12: Dess-Martin oxidation;
DOI:10.1021/ol015652m