(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Base Information

Chemical Name:(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate
CAS No.:1379079-51-2
Molecular Formula:C₂₃H₂₇N₃O₆
Molecular Weight:441.484
Hs Code.:

Synonyms:(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Suppliers and Price of (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

There total 10 articles about (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1379079-50-1
benzyl 3-nitroazetidine-1-carboxylate

: 779342-75-5
tert-butyl 4-chlorobenzylidenecarbamate

: 1379079-51-2
(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Guidance literature:: tert-butyl 4-chlorobenzylidenecarbamate; With CHF₃O₃S*C₃₂H₃₈N₆O₂; In toluene; at 20 ℃;

benzyl 3-nitroazetidine-1-carboxylate; In toluene; at -20 ℃; for 20h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c2cc32225k

Reference yield:

: 1379079-50-1
benzyl 3-nitroazetidine-1-carboxylate

: 779342-75-5
tert-butyl 4-chlorobenzylidenecarbamate

: 1379079-51-2
(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

: (S)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Guidance literature:: With CHF₃O₃S*C₃₂H₃₈N₆; In toluene; at -20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c2cc32225k

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1379079-51-2
(R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water / 0 - 20 °C

2.1: pyridine / dichloromethane / -20 - 20 °C

3.1: sodium iodide / acetone / 2 h / 20 °C

4.1: 3,5-dihydroxyphenol; urea; sodium nitrite / N,N-dimethyl-formamide / 19 h / 50 °C

5.1: CHF₃O₃S*C₃₂H₃₈N₆O₂ / toluene / 20 °C

5.2: 20 h / -20 °C

With pyridine; 3,5-dihydroxyphenol; CHF₃O₃S*C₃₂H₃₈N₆O₂; sodium hydrogencarbonate; urea; sodium iodide; sodium nitrite; In dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 5.1: Aza-Henry reaction;
DOI:10.1039/c2cc32225k