1379079-50-1

Basic information

• Product Name: benzyl 3-nitroazetidine-1-carboxylate
• Synonyms: benzyl 3-nitroazetidine-1-carboxylate
• CAS NO: 1379079-50-1
• Molecular Formula: C₁₁H₁₂N₂O₄
• Molecular Weight: 236.22398
• EINECS: -0
• Mol File: 1379079-50-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl 3-nitroazetidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 3-nitroazetidine-1-carboxylate(1379079-50-1)
• EPA Substance Registry System: benzyl 3-nitroazetidine-1-carboxylate(1379079-50-1)

Safety Data

• Hazardous Substances Data: 1379079-50-1(Hazardous Substances Data)

Upstream product

• 128117-22-6 1-Benzyloxycarbonyl-3-hydroxyazetidine 
• 939759-26-9 benzyl 3-iodoazetidine-1-carboxylate 

Downstream Products

• 1379079-52-3 (S)-benzyl 3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)azetidine-1-carboxylate 
• 1379079-51-2 (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate 

Relevant articles and documents

Chiral proton catalysis of secondary nitroalkane additions to azomethine: Synthesis of a potent GlyT1 inhibitor

The first enantioselective synthesis of a potent GlyT1 inhibitor is described. A 3-nitroazetidine donor is used in an enantioselective aza-Henry reaction catalyzed by a bis(amidine)-triflic acid salt organocatalyst, delivering the key intermediate with 92% ee. This adduct is reductively denitrated and converted to the target through a short sequence, thereby allowing assignment of the absolute configuration of the more potent enantiomer.