trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Base Information

Chemical Name:trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate
CAS No.:1346763-42-5
Molecular Formula:C₂₈H₃₃ClN₂O₇S₂
Molecular Weight:609.164
Hs Code.:

Synonyms:trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Chemical Property of trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

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Technology Process of trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

There total 13 articles about trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1346763-38-9
trans-4-[{2-[({[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-chloro-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexylhydroxyl(di-2-thienyl)acetate

: 1346763-42-5
trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2.5h;

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1346763-42-5
trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / 155 °C

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

5: triethylamine / acetonitrile; tetrahydrofuran / 40 h / 80 °C / High pressure

6: triethylamine / tetrahydrofuran / 20 h / 60 - 80 °C

7: hydrogenchloride / tetrahydrofuran; water / 2.5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile; mineral oil;

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 1346763-42-5
trans-4-[{2-[({[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino}carbonyl)oxy]ethyl}(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 6 h / 65 °C / High pressure

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux

3: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

5: triethylamine / tetrahydrofuran / 20 h / 60 - 80 °C

6: hydrogenchloride / tetrahydrofuran; water / 2.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;