benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate

Base Information

• Chemical Name: benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate
• CAS No.: 457058-51-4
• Molecular Formula: C₁₄H₁₆N₂O₃S
• Molecular Weight: 292.359
• Mol file: 457058-51-4.mol

Synonyms:benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate

Chemical Property of benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate

There total 1 articles about benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl N-<2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate (238748-87-3) → benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate (457058-51-4)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 0.025h;

DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6

Reference yield: 99.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate (457058-51-4) → methyl 2-[2-({[(benzyloxy)carbonyl]amino}ethanethioamido)-2-methylpropanamido]ethanoate

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 120h;

DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6

Reference yield: 74.0%

methyl L-isoleucinate hydrochloride (18598-74-8) + benzyl N-[1-(4,5-dihydro-4,4-dimethyl-5-oxo-1,3-thiazol-2-yl)methyl]carbamate (457058-51-4) → methyl (2S,3S)-2-[2-({[(benzyloxy)carbonyl]amino}ethanethioamido)-2-methylpropanamido]-3-methylpentanoate (457058-63-8)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 120h;

DOI:10.1002/1522-2675(200204)85:4<990::AID-HLCA990>3.0.CO;2-6

upstream raw materials:

benzyl N-<2-<<1,1-dimethyl-2--2-oxoethyl>amino>-2-thioxoethyl>carbamate

Downstream raw materials:

methyl (2S,3S)-2-[2-({[(benzyloxy)carbonyl]amino}ethanethioamido)-2-methylpropanamido]-3-methylpentanoate

(2S,3S)-2-[2-({[(benzyloxy)carbonyl]amino}ethanethioamido)-2-methylpropanamido]-3-methylpentanoic acid