ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

Base Information

Chemical Name:ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate
CAS No.:81504-93-0
Molecular Formula:C₂₆H₂₉NO₅
Molecular Weight:435.52
Hs Code.:

Synonyms:ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

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Chemical Property of ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

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Technology Process of ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

There total 8 articles about ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81504-92-9
8-benzyloxy-5-methoxy-3,4-dihydronaphthalene-2-carboxylic acid

: 5817-26-5
ethyl (2S)-pyrrolidine-2-carboxylate

: 81504-93-0
ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile; at 0 ℃;
DOI:10.1071/CH9841709

Reference yield:

: 1203-34-5
8-hydroxy-5-methoxy-1,2,3,4-tetrahydro-1-naphthalenone

: 81504-93-0
ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / NaOMe / dimethylformamide

2: 95 percent / NaH / tetrahydrofuran / Heating

3: NaBH₄ / methanol / 0 - 5 °C

4: TsOH / benzene / Heating

5: 79 percent / KOH / methanol / Heating

6: 100 percent / dicyclohexylcarbodi-imide / acetonitrile; CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; sodium methylate; sodium hydride; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1039/c39810001100

Reference yield:

: 81504-90-7
methyl 8-benzyloxy-5-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 81504-93-0
ethyl (-)-(2'S)-N-(8-benzyloxy-5-methoxy-3,4-dihydro-2-naphthoyl)prolinate

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 0 - 5 °C

2: TsOH / benzene / Heating

3: 79 percent / KOH / methanol / Heating

4: 100 percent / dicyclohexylcarbodi-imide / acetonitrile; CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1039/c39810001100