2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene

Base Information

• Chemical Name: 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene
• CAS No.: 1314406-56-8
• Molecular Formula: C₁₆H₁₄FN₃O₄
• Molecular Weight: 331.303
• Mol file: 1314406-56-8.mol

Synonyms:2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene

Chemical Property of 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene

There total 4 articles about 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-amino-2-ethoxycarbonylaminonitrobenzene (73895-87-1) + 4-fluorobenzaldehyde (459-57-4) → 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene (1314406-56-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 4h; Reflux;

Reference yield:

2-ethoxycarbonylamino-5-phthalimidonitrobenzene (150812-24-1) → 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene (1314406-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methylamine / isopropyl alcohol; water / 2 h / 60 - 65 °C

2: ethanol / 20 - 65 °C

With methylamine; In ethanol; water; isopropyl alcohol;

Reference yield:

1-ethoxycarbonylamino-4-phthalimidobenzene (721943-05-1) → 2-ethoxycarbonylamino-5-(4-fluorobenzylideneamino)nitrobenzene (1314406-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / acetic acid / 20 - 105 °C / Inert atmosphere

2: methylamine / isopropyl alcohol; water / 2 h / 60 - 65 °C

3: ethanol / 20 - 65 °C

With nitric acid; methylamine; In ethanol; water; acetic acid; isopropyl alcohol;

upstream raw materials:

5-amino-2-ethoxycarbonylaminonitrobenzene

4-fluorobenzaldehyde

N-(4-aminophenyl)carbamic acid ethyl ester

2-ethoxycarbonylamino-5-phthalimidonitrobenzene

Downstream raw materials:

2-ethoxycarbonylamino-5-(4-fluorobenzylamino)nitrobenzene

Retigabine

retigabine dihydrochloride