Retigabine Dihydrochloride

Base Information

Chemical Name:Retigabine Dihydrochloride
CAS No.:150812-13-8
Molecular Formula:C₁₆H₁₈FN₃O₂*ClH
Molecular Weight:339.797
Hs Code.:
UNII:WV9W9019AP
DSSTox Substance ID:DTXSID00164616
Wikidata:Q27292919
Mol file:150812-13-8.mol

Synonyms:Retigabine Dihydrochloride;150812-13-8;Ezogabine Dihydrochloride;Retigabine (dihydrochloride);Retigabine 2HCl;UNII-WV9W9019AP;WV9W9019AP;ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate;dihydrochloride;Retigabine hydrochloride;D20443 dihydrochloride;D 23129 hydrochloride;SCHEMBL155918;DTXSID00164616;Retigabine dihydrochloride- Bio-X;D-23129 2HCl;BCP07747;HY-15471A;s4734;EZOGABINE DIHYDROCHLORIDE [MI];AKOS015994594;AC-5274;ADD-172014;CCG-268364;CS-1136;HE-0244;BR164335;LS-191294;D23129;E98674;Q27292919;N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid (2HCl);ethyl 2-amino-4-(4-fluorobenzylamino)phenylcarbamate dihydrochloride;ethyl N-(2-amino-4-{[(4-fluorophenyl)methyl]amino}phenyl)carbamate dihydrochloride;CARBAMIC ACID, N-(2-AMINO-4-(((4-FLUOROPHENYL)METHYL)AMINO)PHENYL)-, ETHYL ESTER, HYDROCHLORIDE (1:2);N-(2-AMINO-4-(((4-FLUOROPHENYL)METHYL)AMINO)PHENYL)CARBAMIC ACID ETHYL ESTER DIHYDROCHLORIDE

Suppliers and Price of Retigabine Dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Retigabinedihydrochloride >98%
1 g
$ 1000.00

DC Chemicals
Retigabinedihydrochloride >98%
250 mg
$ 500.00

Biosynth Carbosynth
Retigabine dihydrochloride
50 mg
$ 293.00

Biosynth Carbosynth
Retigabine dihydrochloride
10 mg
$ 126.00

AvaChem
Retigabine Dihydrochloride
1g
$ 690.00

AvaChem
Retigabine Dihydrochloride
10mg
$ 119.00

AvaChem
Retigabine Dihydrochloride
100mg
$ 390.00

ApexBio Technology
Retigabinedihydrochloride
100mg
$ 333.00

ApexBio Technology
Retigabinedihydrochloride
50mg
$ 191.00

ApexBio Technology
Retigabinedihydrochloride
10mM (in 1mL DMSO)
$ 80.00

Total 1 raw suppliers

Chemical Property of Retigabine Dihydrochloride

Chemical Property:

Appearance/Colour:Off-white powder
Vapor Pressure:1.34E-07mmHg at 25°C
Melting Point:168-170°C
Boiling Point:430 °C at 760 mmHg
Flash Point:213.9 °C
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:≥18.8 mg/mL in DMSO; ≥52.4 mg/mL in H2O with gentle warming; ≥8.71 mg/mL in EtOH with gentle warming and ultrasonic
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:375.0916604
Heavy Atom Count:24
Complexity:348

Purity/Quality:

99% ^*data from raw suppliers

Retigabinedihydrochloride >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N.Cl.Cl

Technology Process of Retigabine Dihydrochloride

There total 10 articles about Retigabine Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

: 150812-12-7
Retigabine

: 150812-13-8
retigabine dihydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 25 - 30 ℃; for 2h; Solvent; Time;

Reference yield: 62.5%

: 150812-12-7
Retigabine

: 1215347-18-4,150812-13-8
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 2h;

Reference yield:

: 491871-67-1
4-N-[(4-fluorophenyl)methyl]benzene-1,2,4-triamine

: 541-41-3
chloroformic acid ethyl ester

: 150812-13-8
retigabine dihydrochloride

Guidance literature:: 4-N-[(4-fluorophenyl)methyl]benzene-1,2,4-triamine; chloroformic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 10 - 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water; isopropyl alcohol; at 0 - 20 ℃;