methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

Base Information

Chemical Name:methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate
CAS No.:1363364-90-2
Molecular Formula:C₁₅H₁₈N₂O₆
Molecular Weight:322.318
Hs Code.:

Synonyms:methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

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Chemical Property of methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

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Technology Process of methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

There total 3 articles about methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 32980-26-0
2,2-dimethylbutanedioic acid 1-methyl ester

: 5425-81-0
2-amino-1-(4-nitrophenyl)ethanone hydrochloride

: 1363364-90-2
methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

Guidance literature:: 2,2-dimethylbutanedioic acid 1-methyl ester; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With isobutyl chloroformate; In tetrahydrofuran; at -30 - -20 ℃;

2-amino-1-(4-nitrophenyl)ethanone hydrochloride; With triethylamine; In tetrahydrofuran; at -30 - 20 ℃; for 1.08333h;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1363364-90-2
methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / aluminum (III) chloride / 0.67 h

2.1: hexamethylenetetramine / dichloromethane / 1 h

2.2: 51 h

3.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 20 °C

3.2: -30 - -20 °C

3.3: 1.08 h / -30 - 20 °C

With 4-methyl-morpholine; hexamethylenetetramine; bromine; aluminum (III) chloride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1363364-90-2
methyl 2,2-dimethyl-4-(2-(4-nitrophenyl)-2-oxoethylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hexamethylenetetramine / dichloromethane / 1 h

1.2: 51 h

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 20 °C

2.2: -30 - -20 °C

2.3: 1.08 h / -30 - 20 °C

With 4-methyl-morpholine; hexamethylenetetramine; In tetrahydrofuran; dichloromethane;