32980-26-0 Usage
Uses
Used in Pharmaceutical Industry:
1-Methyl 2,2-dimethylsuccinate is used as a key intermediate in the synthesis of peptide amides, which are essential components in the development of various drug molecules. Its unique structure allows for the formation of stable peptide bonds, making it a valuable building block in medicinal chemistry.
Used in the preparation of peptide amide as renin inhibitors:
Specifically, 1-Methyl 2,2-dimethylsuccinate plays a crucial role in the preparation of peptide amides that function as renin inhibitors. These inhibitors are important in the treatment of hypertension and other cardiovascular diseases, as they help regulate the renin-angiotensin-aldosterone system, a key hormonal system involved in blood pressure regulation. By incorporating 1-Methyl 2,2-dimethylsuccinate into the structure of these inhibitors, researchers can enhance their efficacy and selectivity, leading to improved therapeutic outcomes for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 32980-26-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,9,8 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 32980-26:
(7*3)+(6*2)+(5*9)+(4*8)+(3*0)+(2*2)+(1*6)=120
120 % 10 = 0
So 32980-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H12O4/c1-7(2,4-5(8)9)6(10)11-3/h4H2,1-3H3,(H,8,9)
32980-26-0Relevant academic research and scientific papers
COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS
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Page/Page column 95; 96, (2020/01/24)
Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.
A potent, orally bioavailable benzazepinone growth hormone secretagogue
DeVita, Robert J.,Bochis, Richard,Frontier, Alison J.,Kotliar, Andrew,Fisher, Michael H.,Schoen, William R.,Wyvratt, Matthew J.,Cheng, Kang,Chan, Wanda W.-S.,Butler, Bridget,Jacks, Thomas M.,Hickey, Gerard J.,Schleim, Klaus D.,Leung, Kwan,Chen, Zhesheng,Lee Chiu,Feeney, William P.,Cunningham, Paul K.,Smith, Roy G.
, p. 1716 - 1728 (2007/10/03)
The identification of L-739,9.43 (8b), a potent, orally bioavailable benzolactam growth hormone secretagogue, is obtained from zwitterionic L- 692,429 through modification of its amino acid side chain and replacement of the acidic 2'-tetrazole with the ne
