4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

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Chemical Name:4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid
CAS No.:1360821-20-0
Molecular Formula:C₃₀H₂₉Cl₂FN₄O₅
Molecular Weight:615.488
Hs Code.:

4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Synonyms:4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

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Chemical Property of 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

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Technology Process of 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

There total 7 articles about 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1360821-18-6
methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

: 1360821-20-0
4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran;

Reference yield:

: 1000342-80-2
6-chloro-1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one

: 1360821-20-0
4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 0.17 h

1.2: 3 h / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 18 h / 40 °C

3.1: Resolution of racemate

4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

With piperidine; water; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/ml400359z

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1360821-20-0
4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / methanol / 0.17 h

1.2: 3 h / 50 °C

2.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 40 °C

2.2: 18 h / 40 °C

3.1: Resolution of racemate

4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

With piperidine; water; lithium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/ml400359z