1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

Base Information

Chemical Name:1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride
CAS No.:1176738-87-6
Molecular Formula:C₂₉H₃₅NO₅S*ClH
Molecular Weight:546.128
Hs Code.:

Synonyms:1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

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Chemical Property of 1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

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Technology Process of 1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

There total 4 articles about 1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1176736-62-1
[4-(1-Methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylic acid hydrochloride

: 99464-83-2
1-chloroethyl cyclohexyl carbonate

: 1176738-87-6
1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

Guidance literature:: [4-(1-Methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylic acid hydrochloride; 1-chloroethyl cyclohexyl carbonate; With triethylamine; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; at 80 ℃;

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

: 1176736-68-7
4-(2-bromo-9,10-dihydro-1-thiabenzo[f]-azulen-4-ylidene)-1-methylpiperidine

: 1176738-87-6
1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2.1: water; sodium hydroxide / ethanol / Reflux

3.1: triethylamine; potassium iodide / 1,4-dioxane; N,N-dimethyl-formamide / 80 °C

3.2: 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; water; triethylamine; potassium iodide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 15574-96-6
pizotifen

: 1176738-87-6
1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform / 2 h / 0 - 20 °C

2.1: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3.1: water; sodium hydroxide / ethanol / Reflux

4.1: triethylamine; potassium iodide / 1,4-dioxane; N,N-dimethyl-formamide / 80 °C

4.2: 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; water; bromine; triethylamine; potassium iodide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;