(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Base Information

Chemical Name:(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone
CAS No.:1354791-75-5
Molecular Formula:C₂₄H₂₆N₄O₅
Molecular Weight:450.494
Hs Code.:

Synonyms:(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

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Chemical Property of (3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

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Technology Process of (3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

There total 5 articles about (3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 3-methoxyazetidine hydrochloride

: 1254036-06-0
4-((1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yl)oxy)benzaldehyde

: 1354791-75-5
(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: 3-methoxyazetidine hydrochloride; 4-((1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yl)oxy)benzaldehyde; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h;

With water; sodium carbonate; In dichloromethane;

Reference yield: 76.0%

: 1254036-06-0
4-((1-(5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl)azetidin-3-yl)oxy)benzaldehyde

: 110925-17-2
3-methoxyazetidine

: 1354791-75-5
(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1021/acs.jmedchem.5b01654

Reference yield:

: 99367-44-9
ethyl 5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylate

: 1354791-75-5
(3-(4-((3-methoxyazetidin-1-yl)methyl)-phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanide; triethylamine / methanol / 2 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl acetamide / 110 °C

4: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C / Cooling with ice

With sodium cyanide; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/acs.jmedchem.5b01654